The MyDNAge biological age test is one of the few biological age kits based on the original Horvath Clock: the epigenetic model that started it all. Whether you choose blood or urine collection, this at-home test gives you a snapshot of your true biological age based on methylation markers, and even includes bonus insights like metabolic health and Alzheimer’s risk genes.
In this MyDNAge epigenetic test review, we’ll look at how it works, what you’ll learn, and how it stacks up against other aging tests in 2025.
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Table of Contents
What makes MyDNAge different from modern biological age tests?
It uses the original Horvath Clock, the first scientifically validated epigenetic aging model. That gives you a trusted, research-backed result many newer tests build upon.
It’s also the only test offering two sample types:
- 🩸 Blood sample (via finger prick) — recommended for full insights
- 💧 Urine sample — easier to collect, but fewer results included
Users get a clean, science-based report with:
- Your biological age
- A metabolic aging score (blood test only)
- APOE and MTHFR genetic markers
- A short explanation of what’s driving your results
What does the MyDNAge report include?
You’ll get your biological age, plus metabolic age (blood only), and key gene markers like APOE and MTHFR. Everything is delivered in a clear PDF via email.
- Biological Age Estimate
Based on over 2,000 methylation sites, including Horvath’s original 353 CpG markers - Epi-Metabolic Index (blood only)
Gives a score for metabolic aging risk, helpful if you’re tracking inflammation, weight, or insulin sensitivity - APOE Genotype
Screens for longevity and Alzheimer’s-related variants - MTHFR Status
Reveals if your body struggles with methylation (important for folate metabolism, detox, etc.)
The report is emailed as a downloadable PDF, no app or login required.
Is MyDNAge accurate and based on real science?
Yes, it’s one of the most validated tests, used in major aging studies. But it doesn’t show aging speed or organ-specific scores like TruAge.
- ✅ Horvath’s Clock is still widely cited in academic aging research
- 🔬 Over 2,000 methylation markers analyzed using the SWARM™ sequencing method
- 📚 Validated in journals like Nature Scientific Reports, Immunity and Aging, and FASEB Journal
- 🔁 Strong test–retest consistency for tracking lifestyle changes
That said, it doesn’t offer organ-level aging, telomeres, or pace-of-aging metrics like newer tests do.
Who is the MyDNAge test best for?
This test is ideal for:
- 🧬 Science-focused users who want a classic, Horvath-based result
- 🩸 People willing to do a small finger-prick for higher accuracy
- 🧪 Users interested in methylation + APOE + MTHFR status in one test
- 💰 Biohackers who want a one-time, no-subscription test
- 📈 Repeat testers tracking lifestyle or supplement changes over time
It’s not built for beginners or those who want an app experience. But if you want raw epigenetic science in a clear report, it delivers.
How do you take the MyDNAge age test at home?
Choose blood or urine, register the barcode, send it back, and get your PDF results in 4–6 weeks. The blood version gives more detailed insights.
- Choose your version: Blood (more complete) or Urine (simpler)
- Order the kit online and register your barcode
- Collect the sample at home using the kit instructions
- Ship it to the lab (shipping paid)
- Get your report via email in 4–6 weeks
- Compare your biological vs chronological age
- Use the insight to guide your health habits
- Retest after 6–12 months to see what changed
How does MyDNAge compare to other aging tests?
🧬 MyDNAge vs TruAge
TruAge uses blood and gives organ aging, aging speed, and 11 system reports. It’s more complete, but more expensive and complex. MyDNAge is science-first and simple.
🧠 MyDNAge vs NOVOS
Both use blood and methylation. NOVOS adds DunedinPACE and an AI dashboard. MyDNAge keeps it classic with Horvath’s clock and adds APOE + metabolic risk.
📊 MyDNAge vs EasyDNA
EasyDNA is cheaper and beginner-friendly. MyDNAge is far more scientific, with deeper validation and extra genetic markers.
💡 MyDNAge vs Tally
Tally is app-based and habit-focused. MyDNAge is lab-based and focused purely on methylation and genetics.
Pricing, access, and turnaround
💵 Price: $299
💉 Sample Type: Blood or Urine
📄 Report Format: Email PDF
📦 Shipping: Available in US, Canada, EU, Australia
🕓 Turnaround Time: 4–6 weeks
🏥 HSA/FSA Eligible: ❌ No
📱 App or Coaching: ❌ No app, no coaching
🔁 Retesting Support: Yes (manual comparison)
What are real users saying about MyDNAge?
🧠 On Reddit:
- “Blood version is way better than the urine one.”
- “It’s old-school but still solid. I use it every 6 months to track NMN and fasting.”
- “APOE was a nice bonus. Helped me rethink my sleep and supplements.”
💬 On Quora:
- Frequently praised by early biohackers
- Often mentioned as a credible test for first-timers who don’t need apps
- Some wish results were faster or came with explanations
FAQs
Is the MyDNAge blood test more accurate than urine?
Yes. The blood test includes the full methylation report, metabolic index, and genetic markers. The urine test is easier but offers limited insights.
Can I use MyDNAge to measure effects of supplements or fasting?
Yes, especially if you retest after 3–6 months. It won’t track habits directly but will reflect biological changes through your methylation age.
Does MyDNAge include aging pace like DunedinPACE?
No. It uses Horvath’s clock to estimate biological age, not your current aging speed. Tests like TruAge or NOVOS offer pace-of-aging metrics.
Can I get my raw methylation or genetic data?
No, MyDNAge does not currently provide raw data files like VCF or FASTQ. You’ll only receive a summarized PDF report.
What does the Epi-Metabolic Index actually show?
It’s an estimate of how your body is aging from a metabolic standpoint, influenced by inflammation, weight, and related markers. Only included in the blood version.
How do I interpret my APOE result?
APOE genotypes can impact longevity and Alzheimer’s risk. If you receive the APOE4 variant, it’s best to speak with a healthcare provider about lifestyle adjustments.
Can I take the test outside the U.S.?
Yes. MyDNAge ships to the EU, Canada, and Australia, but not Asia or South America. Make sure your country is listed during checkout.
Written by the editorial team at Simply Anti-Aging.
Reviewed for accuracy and updated in July 2025.
